Allow me to paraphrase the extensive answer by a Samsung employee.
TL;DR, yes you can and you should!
Thank you for contacting Samsung Support regarding your concerns and inquiries. We apologize for any inconvenience this may be causing you.
Trim is mandatory for all SSDs. We have seen claims form other manufactures that they have TRIM support in their firmware or that it is unnecessary. These claims are false. Trim is an operating system distributed command that tells the SSD which information to delete or is no longer valid. This allows the SSD to skip over invalid data when performing Garbage Collection instead of moving around old data. Trim does not remove or erase all of your data from your SSD. Trim assists Garbage Collection by preparing invalid data for deletion.
Garbage Collection is part of the SSD and is not user / OS controlled. Garbage collection actually involves the collection and restacking of good data together, not garbage data. This reorganization of data makes it easier to clean up the invalid data or data marked for deletion and keeps performance optimal. Using the Garbage Collection alone is not enough to keep the SSD working properly which means your SSD would die quickly.
Certain Apple machines and Operating Systems will work best our SSDs. The following must be understood before purchasing our product or any SSD for an Apple computer::
1) You can use the terminal Trim Force command in lieu of Trim Enabler for Mac, Disk Sensei, or Chameleon. Before you enable Trim with Trimforce, be sure to Disable Trim though the program that you were using.
The following link will explain in detail why Yosemite has (or had) ”problems” with Trim Enabler. The TL;DR (Too Long ; Didn’t Read) section summarizes why if you do not care for the full details. However, it is recommended that you read the entire article: https://www.cindori.org/trim-enabler-and-yosemite/
To download Trim Enabler for Mac (instead of using Trimforce) here: http://www.cindori.org/software/trimenabler/
Samsung is not affiliated with this developer and is only providing this information because we want you to enjoy our SSDs without long term frustration. Trim will keep your SSD healthier and working longer than if you decided to work without the program. It’s up to you to decide if you want paid version of the software ($10). The free version has the TRIM support but the paid version has the ability to make the additional setting changes to preserve the SSD.
Should you decide to use the Paid Trim Enabler or Disk Sensei version, here are the settings to use:
Turn on: Trim and Check for Trim at Boot.
Turn off : Sleep Image, Sudden Motion Senor, and Time Machine
Next, you must go to your System Preferences for more changes. Under Power options, set the computer to never sleep under the Battery and Power Adapter settings.
SSDs are never supposed to go to sleep. This means you either are using the computer or it is turned off. You can leave the display to dim at whatever minute amount you like.
2) Apple will not allow us to make any software for our SSDs and their machines. You will have to find your own cloning software. The performance boosting features of our Magician program will not available to Apple users. Some users have reported using Carbon Copy Cloner or Super Duper to clone to the SSD. Currently no substitutions for Magician have been made by a third party and are unlikely to occur since it is our proprietary software for our SSDs.
3) Before you use the SSD you must initialize and format the SSD in Disk Utility via a SATA to USB Cable. The drive takes GUID and formats in Apple Extended (Journaled).
4) Performance cannot be changed or upgraded in anyway with any Apple machine. Any apple computers from 2007 up to early 2011 can still possibly be using the negotiated link speed of SATA 1, not the listed Link Speed of SATA 2. Some 2011 machines are using the negotiated link speed of SATA 2 or 3. These SATA2 and 3 specs are good enough to enjoy the performance increase from our SSD. Please check your SATA hardware information to determine the negotiated link speed and if this performance is acceptable for you. The 2012 Models use SATA 3. This is last model year you can use our SSDs for. Be sure that you have a 2012 model that was built before the Retina version. Retina versions and beyond 2012 do not typically use or accept our retail SSDs
Thank you again for contacting Samsung Support and have a good day.